Studio sull’impatto ambientale delle attività di maricoltura nel Golfo di Oristano

L’obiettivo del presente lavoro è stato di simulare la dispersione e il tempo di residenza delle sostanze organiche immesse nell’ambiente a seguito delle attività di acquacoltura all’interno del Golfo di Oristano (Sardegna, Italia). A questo scopo è stato implementato un modello numerico di circolazione, con moduli di dispersione e diffusione euleriana e lagrangiana. Il modello ha evidenziato il ruolo fondamentale della direzione e dell’intensità del vento sulla dispersione dei rifiuti organici. A parità d’intensità, la direzione del vento influenza in maniera decisiva la distanza alla quale i rifiuti organici vengono trasportati e depositati. In tutti gli scenari di vento, il mangime non consumato, indipendentemente dalla sua dimensione, si deposita in un’area direttamente sotto le gabbie ma con una distribuzione spaziale che dipende dalle correnti indotte. In tutti i casi, la materia organica disciolta si diluisce ed è trasportata al di fuori del golfo. Con i venti da Maestrale i rifiuti organici sono spinti verso, l’interno del golfo per poi uscirne in forma disciolta da sud. Negli scenari di Libeccio e Scirocco i rifiuti organici disciolti tendono a diluirsi ed essere trasportati al di fuori del golfo dalla parte nord. In tutti gli scenari, la capacità di ricambio delle acque interne al golfo risulta elevata, con la maggior parte delle sostanze organiche disciolte presenti in concentrazioni molto basse dopo dieci ore dalla loro produzione. Dal punto di vista del ricambio d’acqua e conseguentemente per la dispersone di agenti inquinanti, quasi tutti i 13 siti simulati, ad esclusione dei due in prossimità dei capi, hanno tempi di residenza idonei per il posizionamento delle gabbie. Sono comunque da preferire le regioni più a sud perché i tempi di transito sono più bassi creando un impatto minore. Infine considerando che il golfo è ricoperto quasi interamente da Posidonia, i siti meno impattanti sono quelli che si trovano su un fondale fangoso e in prossimità del fiume Tirso (Sito 3 e 4). L’utilizzo di modelli numerici ha permesso di portare a termine studi a priori (tempi di transito, zone di deposizione, dispersioni inquinanti) per la pianificazione della disposizione ottimale delle gabbie, avente come conseguenza una più proficua produzione (maggiore redditività) e un minore impatto ambientale. Si può infine affermare che nonostante l’assenza di studi antecedenti al presente, le gabbie all’interno del Golfo di Oristano siano state posizionate correttamente, in una regione ottimale per produzione e impatto ambientale

Augmented Reality to Guide Selective Clamping and Tumor Dissection During Robot-assisted Partial Nephrectomy: A Preliminary Experience.

ABSTRACT Introduction to explore the feasibility of augmented reality (AR) to guide arterial clamping during robot-assisted partial nephrectomy (RAPN). Patients and Methods 15 consecutive patients with T1 renal mass underwent RAPN guided by AR. The 3D virtual model derived by computed tomography was superimposed on the actual view provided by the Da Vinci video stream thought AR technology. Preoperative plan of arterial clamping based on 2D conventional imaging, on 3D model and the effective intraoperative surgical approach guided by AR were compared using the McNeamar test. Results The plan of arterial clamping based on 2D preoperative imaging was recorded as follows: no clamping in 3 (20%), clamping of the main artery in 10 (66.7%) and selective clamping in 1 (6.7%) and super-selective clamping in 1 (6.7%) cases. After revision of the 3D model, the plan of clamping was modified as follows: no clamping in 1 (6.7%), clamping of the main artery in 2 (13.3%), selective clamping in 8 (53.3%) and super-selective clamping in 4 (26.7%) cases (p=0.03). The effective intraoperative clamping approach guided by AR-guidance was performed as planned in 13 (86.7%) patients. Conclusion AR for 3D guided renal surgery is useful to increase the adoption of selective clamping during RAPN

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Do handwriting difficulties of Parkinson's patients depend on their impaired ability to retain the motor plan? A pilot study

Patients affected by Parkinson’s disease (PD) show deficits in learning novel motor behaviors and executing previously acquired ones. We investigated whether the two phenomena are related, evaluating the hypothesis that PD patients have difficulties in executing fine movements (such as handwriting) acquired before the onset of the disease since they perform the task as they are executing it for the first time. We asked healthy subjects to write a sequence of ‘l’ on a digitizer tablet by drawing the loop of the letter in counterclockwise fashion (as they are used to do) and clockwise fashion (i.e. using a novel motor plan). We compared the kinematic features of the samples produced by healthy subjects to those measured in samples produced by PD patients. We focused the analysis on the ink trace segmentation points, which represent the starting/ending points of the elementary handwriting movements. Our results suggests that deficits observed in PD patients in executing both novel tasks (reduced learning performance compared to controls) and previously acquired task (disrupted kinematic features compared to controls) could be due to the same underlying deficit, i.e. impaired ability of PD patients to retain the motor plan associated to the task

A paradigm for emulating the early learning stage of handwriting: Performance comparison between healthy controls and Parkinson's disease patients in drawing loop shapes

We present a novel paradigm, aimed at emulating the early stage of handwriting learning in proficient writers, by asking them to produce a familiar shape through a novel (unfamiliar) motor plan. Handwriting of beginner writers is characterized by slower movements, reduced spatial precision, lower fluency and reduced force regulation compared to those observed in the handwriting production of proficient writers. Features observed in the ink trace obtained with the novel motor plan and performance comparison of the handwriting obtained by familiar and unfamiliar motor plan suggest that the proposed paradigm is able to elicit non-automated movements in proficient writers. As that produced by beginner writers, handwriting of Parkinson's disease (PD) patients is characterized by lack of fluency, slowness and abrupt changes of direction. Furthermore, PD patients show impaired performance in learning novel motor behaviors, as well as in executing motor behaviors acquired before the onset of the disease. We used the proposed paradigm for comparing the performance achieved by healthy controls in writing a familiar shape through a novel motor plan with those obtained by PD patients performing a well-known motor plan for drawing the same shape. Our analysis points out some similarities between performance obtained by healthy controls and those obtained by PD patients, sustaining the hypothesis that the fine tuning of the motor plan parameters involved in the handwriting production is impaired by PD